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经验配方 CAS号 C₂₁H₂₆N₂O₇ 66085-59-4 描述 概述 An L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells. 产品目录编号 482200 品牌系列 Calbiochem®
同义词 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester 参考 参考 Zhu, D., et al. 1999. Life. Sci. 65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.产品信息 CAS号 66085-59-4 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₂₁H₂₆N₂O₇ 化学配方 C₂₁H₂₆N₂O₇ Molar Mass 418.4 可逆 N 结构配方图像 生物信息 主靶 L-type Ca2+ channel blocker 主靶IC50 36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells 纯度 >98% by TLC 理化信息 细胞可渗透 N 溶解度 DMSO or MeOH GHS安全信息 RTECS US7975500 安全信息 R相 R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.S相 S: 36
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful & Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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