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  • merck millipore,默克密理博,IL037,Interleukin-4 Protein, Recombinant rat

  • merck millipore,默克密理博,IL037,Interleukin-4 Protein, Recombinant rat

    产品名称：Interleukin-4 Protein, Recombinant rat
    产品型号：IL037
    The recombinant rat Interleukin-4 protein (or IL-4 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.

    merck millipore,默克密理博,IL037,Interleukin-4 Protein, Recombinant rat

  • 产品介绍
  • merck millipore,默克密理博,IL037,Interleukin-4 Protein, Recombinant rat

    重要规格表

    主要应用 品种 纯度
    CULTRatGreater than 98% by SDS-PAGE and HPLC analysis
    描述
    产品目录编号 IL037
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Interleukin-4 Protein, Recombinant rat
    概述 Interleukin-4 (IL-4) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B cells and T cells. IL037 is a 14 kDa protein containing 121 amino acid residues.
    Alternate Names
    • IL-4
    产品信息
    演示 Lyophilized powder with no additives.
    应用
    应用 The recombinant rat Interleukin-4 protein (or IL-4 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.
    主要应用
    • Cell Culture
    应用说明 For most in vitro applications, IL-4 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL.
    生物信息
    纯度 Greater than 98% by SDS-PAGE and HPLC analysis
    品种 Rat
    特异活性 Chemicon's IL-4 is fully biologically active when compared to standards. The ED50 of IL037 as determined by the dose-dependent stimulation of the proliferation of con-A-activated rat spleen cells was found to be </= 1.5 ng/mL, corresponding to a specific activity of >/= 6.6 x 10E5 units/mg.
    Entrez基因汇总 The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
    UniProt编号
    • P20096
    • P05112
    UniProt汇总 FUNCTION: SwissProt: P05112 # Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
    SIZE: 153 amino acids; 17492 Da
    SUBCELLULAR LOCATION: Secreted.
    DISEASE: SwissProt: P05112 # Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    SIMILARITY: SwissProt: P05112 ## Belongs to the IL-4/IL-13 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized IL-4, though stable at room temperature, is best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for one week or at -20°C for future use. Reconstituted IL-4 should be stored in working aliquots at -20°C for up to 6 months.
    包装信息
    数量 20 µg

    merck millipore,默克密理博,IL037,Interleukin-4 Protein, Recombinant rat

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