merck millipore,默克密理博,475889,MK-886 - CAS 118414-82-7

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merck millipore,默克密理博,475889,MK-886 - CAS 118414-82-7 - Calbiochem
产品名称：MK-886 - CAS 118414-82-7 - Calbiochem
产品型号：475889
A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation More>>

merck millipore,默克密理博,475889,MK-886 - CAS 118414-82-7 - Calbiochem

产品介绍

merck millipore,默克密理博,475889,MK-886 - CAS 118414-82-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₇H₃₃ClNO₂S · Na	118414-82-7

描述
概述	A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E₂) production by inhibiting COX-1 and mPGES-1 (microsomal PGE₂ synthase-1), but not COX-2, activity (IC₅₀ = 8, 2, and 58 µM, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1 µM MK-886). Unlike NSAIDs (nonsteroidal antiinflammatory drugs) that target only COX pathway, MK-886 does not cause gastrointestinal damages when applied in vivo.
产品目录编号	475889
品牌系列	Calbiochem®
同义词	3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic Acid, Na, COX-1 Inhibitor III, FLAP Inhibitor I, MK886, mPGES-1 Inhibitor I

参考
参考	Koeberle, A., et al. 2009. Eur. J. Pharmacol. 608, 84. Koeberle, A., et al. 2008. J. Pharmacol. Exp. Ther. 326, 975. Fisher, L., et al. 2007. Br. J. Pharmacol. 152, 471. Ford-Hutchinson, A.W., et al. 1993. Can. J. Physiol. Pharmacol. 71, 806. Ford-Hutchinson, A.W. 1991. Trends Pharmacol. 12, 68. Dixon, R.A., et al. 1990. Nature 343, 282. Rouzer, C.A., et al. 1990. J. Biol. Chem. 265, 1436.

参考

Koeberle, A., et al. 2009. Eur. J. Pharmacol. 608, 84.
Koeberle, A., et al. 2008. J. Pharmacol. Exp. Ther. 326, 975.
Fisher, L., et al. 2007. Br. J. Pharmacol. 152, 471.
Ford-Hutchinson, A.W., et al. 1993. Can. J. Physiol. Pharmacol. 71, 806.
Ford-Hutchinson, A.W. 1991. Trends Pharmacol. 12, 68.
Dixon, R.A., et al. 1990. Nature 343, 282.
Rouzer, C.A., et al. 1990. J. Biol. Chem. 265, 1436.

产品信息
CAS号	118414-82-7
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₇H₃₃ClNO₂S · Na
化学配方	C₂₇H₃₃ClNO₂S · Na
Molar Mass	494.0
可逆	N
结构配方图像

生物信息
主靶	leukotreine biosybthesis
主靶IC₅₀	102 nM
纯度	≥99% by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
无需冷冻	No
特殊指南	Unstable in solution; reconstitute just prior to use.