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品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 CBL47 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Transferrin Receptor Antibody Alternate Names - TFR
- CD71
产品信息 格式 Purified 演示 The polyclonal is presented at 100μg in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Detect Transferrin Receptor using this Anti-Transferrin Receptor Antibody validated for use in ELISA. 主要应用 - ELISA
应用说明 Study of cellular proliferation and lymphocyte activation.
Cell surface expression of transferrin receptors is correlated with relative cell growth rate of malignant and non-malignant cells.
Transferrin receptors are virtually absent from resting PBLs.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified human placental transferring receptor 宿主 Rabbit 特异性 Human Transferrin Receptor which is expressed on proliferating lymphoblasts, majority human tumour cell lines, normal peripheral blood monocytes.
Antigen Distribution:
Con A activated lymphocytes__________67 + 27%
PHA activated lymphocytes___________67 + 27%
Monocytes________________________40 + 20%
Thymocytes_______________________22 + 7%
Peripheral blood lymphocytes_________< 3%
B cells (E-)________________________< 1%
T cells (E+)________________________< 1%
NK cells (CD16+)___________________< 1%
Granulocytes_______________________< 1%品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003234.1
基因符号 - TRFR
- TFRC
- TfR
- T9
- TfR1
- TFR
- p90
- Trfr
- TR
- TFR1
- CD71
UniProt编号 - P02786
UniProt汇总 FUNCTION: SwissProt: P02786 # Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
SIZE: 760 amino acids; 84871 Da
SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. & Transferrin receptor protein 1, serum form: Secreted.
PTM: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. & Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). & Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
SIMILARITY: SwissProt: P02786 ## Belongs to the peptidase M28 family. M28B subfamily. & Contains 1 PA (protease associated) domain.
MISCELLANEOUS: Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. & Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 µg
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