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merck millipore,默克密理博,428205,Lck Inhibitor - CAS 213743-31-8 - Calbiochem
产品名称：Lck Inhibitor - CAS 213743-31-8 - Calbiochem
产品型号：428205
The Lck Inhibitor, also referenced under CAS 213743-31-8, controls the biological activity of Lck. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,428205,Lck Inhibitor - CAS 213743-31-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₂N₄O 213743-31-8 描述 概述 A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC50 at 5 µM ATP = < 1 nM, 2 nM, 70 nM, 1.57 µM and 1.98 µM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 µM, 66 nM, 126 nM, 420 nM and 5.18 µM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC50 = 3.2 µM, > 33 µM, > 50 µM and > 50 µM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50 < 1-40 nM in Jurkat T cells) and in vivo (ED50 = 4 mg/kg in mice, ip.) 产品目录编号 428205 品牌系列 Calbiochem®
同义词 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane 参考 参考 Burchat, A.F., et al. 2000. Bioorg. Med. Chem. Lett. 10, 2171.
Arnold. L.D., et al. 2000. Bioorg. Med. Chem. Lett. 10, 2167.产品信息 CAS号 213743-31-8 具有ATP竞争性 Y 形式 White solid Hill配方 C₂₃H₂₂N₄O 化学配方 C₂₃H₂₂N₄O Molar Mass 370.5 可逆 Y 结构配方图像 生物信息 主靶 Lck₆₄₋₅₀₉ Y³⁹⁴ 主靶IC50 At5 µM ATP = < 1 nM, 2 nM, 70 nM, 1.57 µM and 1.98 µM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 µM, 66 nM, 126 nM, 420 nM and 5.18 µM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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