merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1105,Anti-RelB Antibody

  • merck millipore,默克密理博,06-1105,Anti-RelB Antibody

    产品名称：Anti-RelB Antibody
    产品型号：06-1105
    Use Anti-RelB Antibody (rabbit polyclonal antibody) validated in WB,IHC(P) to detect RelB also known as reticuloendotheliosis viral oncogene homolog B, v-rel avian reticuloendotheliosis viral oncogene More>>

    merck millipore,默克密理博,06-1105,Anti-RelB Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1105,Anti-RelB Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rhesus Macaque, H, M, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1105
    Replaces 04-1077
    描述 Anti-RelB Antibody
    Alternate Names
    • v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in -cells 3
    • reticuloendotheliosis viral oncogene homolog B
    • v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
    • v-rel reticuloendotheliosis viral oncogene homolog B
    背景信息 NFĸB (Nuclear Factor kappa B) represents a group of transcription factors that are structurally related and evolutionarily conserved proteins related to the proto-oncogene c-Rel. The five members in mammals includes Rel (cRel), RelA (p65), RelB, NFĸB1 (p50 and its precursor p105), and NFĸB2 (p52 and its precursor p100). NFĸB/Rel proteins exist as homo- or heterodimer complexes. In a majority of unstimulated cells, the NFĸB transcription factors are bound to the inhibitory IĸB proteins and retained in the cytoplasm in their inactive form. RelB is a component of the NFĸB RelB-p50 complex and the RelB-p52 complex. RelB's interaction in complex seems to be transient and prevents degradation, allowing for heterodimer formation with p50 or p52.
    产品信息
    格式 Affinity Purified
    控制
    • Raji cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-RelB Antibody (rabbit polyclonal antibody) validated in WB,IHC(P) to detect RelB also known as reticuloendotheliosis viral oncogene homolog B, v-rel avian reticuloendotheliosis viral oncogene homolog B.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:400 dilution from a previous lot detected RelB in ductal carcinoma in situ tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human RelB at the RHD domain.
    表位 RHD domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes RelB at the RHD domain.
    品种反应性 Rhesus MacaqueHumanMouseRat
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    Predicted to react with rhesus macaque based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_006500
    基因符号
    • RelB
    • I-REL
    • I-Rel
    • IREL
    纯化方法 Affinity Purified
    UniProt编号
    • Q01201
    UniProt汇总 FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.

    SUBUNIT STRUCTURE: Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID By similarity.

    SUBCELLULAR LOCATION: Nucleus.

    INDUCTION: By mitogens.

    DOMAIN: Both N- and C-terminal domains are required for transcriptional activation.

    PTM: Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation By similarity.

    SEQUENCE SIMILARITIES: Contains 1 RHD (Rel-like) domain.

    CAUTION: Was originally (Ref.1) thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B.
    产品使用声明
    质量保证 Evaluated by Western Blot in Raji cell lysate.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected RelB in 10 µg of Raji cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1105,Anti-RelB Antibody

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