- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₀O₆ 520-18-3 描述 概述 A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM). 产品目录编号 420345 品牌系列 Calbiochem®
同义词 3,4ʹ,5,7-Tetrahydroxyflavone 参考 参考 Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
Wang, H., et al. 2000. Phytomedicine 7, 15.
Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.产品信息 CAS号 520-18-3 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₅H₁₀O₆ 化学配方 C₁₅H₁₀O₆ Molar Mass 286.2 可逆 N 结构配方图像 生物信息 主靶 Topoisomerase I-catalyzed DNA religation in HL-60 cells 主靶IC50 180 µM against COX-1 activity 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS LK9275200 安全信息 R相 R: 36/37/38-40
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.S相 S: 22-26-36
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,AB9766-200UL,Anti-Kv12.1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,09-069,Anti-ATF6 Antibody
相关产品
merck millipore,默克密理博,SF-2077,ATG5; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,04-366,Anti-IKK beta Antibody, clone Y466, rabbit monoclonal
merck millipore,默克密理博,444249,MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem
merck millipore,默克密理博,AB9766-200UL,Anti-Kv12.1 Antibody
merck millipore,默克密理博,09-069,Anti-ATF6 Antibody
merck millipore,默克密理博,14-569,ErbB4 Protein, active, 10 µg
merck millipore,默克密理博,MAB3576,Anti-Caldesmon Antibody, smooth muscle, clone N5/22
merck millipore,默克密理博,DC05L,Goat Anti-Mouse IgG Alkaline Phosphatase Conjugate
merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)