merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)

  • merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)

    产品名称：Anti-phospho-TBC1D1 Antibody (Ser237)
    产品型号：07-2268
    This phospho-TBC1D1 antibody is validated for use in WB for the detection of the phospho-TBC1D1 protein.

    merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)

  • 产品介绍
  • merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ox, H, M, R, Chp, Rhesus MacaqueWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2268
    描述 Anti-phospho-TBC1D1 Antibody (Ser237)
    Alternate Names
    • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
    • TBC1 domain family member 1
    背景信息 TBC1D1 is the first member of a family of proteins that contain the tbc box motif of 180-220 amino acids and may be related to cell growth and differentiation. The composition of TBC1D1 has the same function as a known regulator of insulin-mediated Glut4 translocation and may play a role in severe human obesity. An insulin-independent increase in glucose transport several hours after exercise has been attributed to TBC1D1 phosphorylation. The R125W mutation of TBC1D1 is thought to decrease skeletal muscle glucose transport and could be the main reason for the obesity that seems to be linked to this type of mutation.
    产品信息
    格式 Affinity Purified
    控制
    • Lambda phosphatase treated and untreated HEK293 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This phospho-TBC1D1 antibody is validated for use in WB for the detection of the phospho-TBC1D1 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human TBC1D1 phosphorylated at Ser237.
    表位 Phosphorylated Ser237
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes TBC1D1 phosphorylated at Ser237.
    品种反应性 OxHumanMouseRatChimpanzeeRhesus Macaque
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, rat, chimpanzee, rhesus macaque, and ox based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_055988
    Entrez基因汇总 TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM].
    基因符号
    • TBC1
    • TBC1D1
    • TBC
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q86TI0
    UniProt汇总 FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues (By similarity).

    SUBCELLULAR LOCATION: Nucleus (By similarity).

    SEQUENCE SIMILARITIES: Contains 1 PID domain.

    Contains 1 Rab-GAP TBC domain.

    SEQUENCE CAUTION: The sequence BAB55057.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in lambda phosphatase treated and untreated HEK293 cell lysates.

    Western Blot Analysis: 1 µg/mL of this antibody detected TBC1D1 on 10 µg of lambda phosphatase treated and untreated HEK293 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2268,Anti-phospho-TBC1D1 Antibody (Ser237)

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