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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9766-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Kv12.1 Antibody Alternate Names - Elk1, KCNH8, ether-a-go-go like K<sup>+</sup> channel 3, Voltage gated K<sup>+</sup> channel subfamily H member 8
- Elk1
- KCNH8
- ether-a-go-go like K<sup>+</sup> channel 3
产品信息 格式 Affinity Purified 控制 - Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 µL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 This Anti-Kv12.1 Antibody is validated for use in WB for the detection of Kv12.1. 主要应用 - Western Blotting
应用说明 Western blot: 1:200 using ECL on rat cortex lysate.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from amino acids 143-157 of rat Kv12.1 . 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Kv12.1 (Elk1, KCNH8, ether-a-go-go like K+ channel 3, Voltage gated K+ channel subfamily H member 8). 品种反应性 RatHuman Species Reactivity Note The immunogen sequence is 14 of 15 amino acids identical in mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_145095
基因符号 - ELK1
纯化方法 Immunoaffinity purified UniProt编号 - Q9QWS8
UniProt汇总 Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Subunit structure: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Detected in superior cervical, mesenteric and coeliac ganglia. Expressed in brain (piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus). Expressed in pituitary.
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities: Belongs to the potassium channel family. H (Eag) subfamily.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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