merck millipore,默克密理博,401003,(±)-Ibuprofen - CAS 15687-27-1

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merck millipore,默克密理博,401003,(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem
产品名称：(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem
产品型号：401003
A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

merck millipore,默克密理博,401003,(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

产品介绍

merck millipore,默克密理博,401003,(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

重要规格表

经验配方	CAS号
C₁₃H₁₈O₂	15687-27-1

描述
概述	A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM). Inhibits COX-2 at higher concentrations (IC₅₀ = 223 µM). Blocks aspirin inactivation of COX-1 (EC₅₀ antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β_{40 and 42}) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
产品目录编号	401003
品牌系列	Calbiochem®
同义词	[(±)-2-(4-Isobutylphenyl)-propionic Acid

参考
参考	Asanuma, M., et al. 2001. J. Neurochem. 76, 1895. Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094. Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583. Casper, D., et al. 2000. Neurosci. Lett. 289, 201. Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249. Lim, G.P., et al. 2000. J. Neurosci. 20, 5709. Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137. Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973. Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406. Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S. Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

参考

Asanuma, M., et al. 2001. J. Neurochem. 76, 1895.
Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.

产品信息
CAS号	15687-27-1
具有ATP竞争性	Y
形式	White solid
Hill配方	C₁₃H₁₈O₂
化学配方	C₁₃H₁₈O₂
Molar Mass	206.3
可逆	Y
结构配方图像

生物信息
主靶	COX-1
主靶IC₅₀	4.85 µM against COX-1
纯度	≥98% by titration

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

GHS安全信息
RTECS	MU6640000

安全信息
R相	R: 22 Harmful if swallowed.
S相	S: 36 Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Harmful
储存	+15°C to +30°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

merck millipore,默克密理博,401003,(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

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