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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 07-614 品牌系列 Upstate
商名 - Upstate
描述 Anti-Surfactant Protein B Antibody 产品信息 格式 Serum 演示 rabbit antiserum containing 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-Surfactant Protein B Antibody is an antibody against Surfactant Protein B for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 Purified human surfactant protein B 宿主 Rabbit 特异性 Surfactant Protein B 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因汇总 The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM] 基因符号 - SMDP1
- SFTPB
- SP-B
- SFTP3
- Phe
- PSP-B
- SFTB3
纯化方法 Serum UniProt编号 - P07988
UniProt汇总 FUNCTION: SwissProt: P07988 # Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
SIZE: 381 amino acids; 42117 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted, extracellular space.
DISEASE: SwissProt: P07988 # Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).
SIMILARITY: SwissProt: P07988 ## Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).产品使用声明 质量保证 routinely evaluated by immunoblot on human bronchiolar lavage fluid. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 50 µL
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