merck millipore,默克密理博,691550,Zinc (II) Protoporphyrin IX - CAS 15442-64-5

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merck millipore,默克密理博,691550,Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
产品名称：Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
产品型号：691550
A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

merck millipore,默克密理博,691550,Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

产品介绍

merck millipore,默克密理博,691550,Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

重要规格表

经验配方	CAS号
C₃₄H₃₂N₄O₄Zn	15442-64-5

描述
概述	A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
产品目录编号	691550
品牌系列	Calbiochem®
同义词	ZnPP-9

参考
参考	Wolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27. Bing, O., et al. 1995. NeuroReport 6, 1369. Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455. Kadoya, C., et al. 1995. Stroke 26, 1035. Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186. Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263. Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753. Zhuo, M., et al. 1993. Science 260, 1946.

参考

Wolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
Bing, O., et al. 1995. NeuroReport 6, 1369.
Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
Kadoya, C., et al. 1995. Stroke 26, 1035.
Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
Zhuo, M., et al. 1993. Science 260, 1946.

产品信息
CAS号	15442-64-5
具有ATP竞争性	N
形式	Dark red solid
Hill配方	C₃₄H₃₂N₄O₄Zn
化学配方	C₃₄H₃₂N₄O₄Zn
Molar Mass	626.0
可逆	N
结构配方图像

生物信息
主靶	heme oxygenase
主靶IC₅₀	800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively
纯度	≥95% by TLC

理化信息
细胞可渗透	N
溶解度	DMF or pyridine

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C).