merck millipore,默克密理愽
  • merck millipore,默克密理博,385570,Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem

  • merck millipore,默克密理博,385570,Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem

    产品名称：Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem
    产品型号：385570
    The Heat Shock Factor 1 Inhibitor, KRIBB11 controls the biological activity of Heat Shock Factor 1.

    merck millipore,默克密理博,385570,Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,385570,Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem

    重要规格表

    经验配方
    C₁₃H₁₂N₆O₂
    描述
    概述 A cell-permeable 2,6-diaminopyridine compound that interacts with HSF1 in a reversible manner and prevents HSF1 from recruiting p-TEFb to the hsp70 promoter site (IC50 ≤3 µM in HCT-116 ChIP assays), a critical step for heat shock-induced transcription activation (IC50 <1, <3, <5, and <10 µM, respectively, against reporter, HSP47, HSP27, and HSP70 transcription in HCT-116 cultures). Reported to exhibit antiproliferation activity against several cancer cultures in vitro (IC50 from 3 to 8 µM) and effectively suppress HCT-116-derived tumor growth in mice in vivo (50 mg/kg i.p.).
    产品目录编号 385570
    品牌系列 Calbiochem®
    同义词 N²-(1H-Indazol-5-yl)-N⁶-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor, Hsp70 Induction Inhibitor II
    参考
    参考 Yoon, Y.J., et al. 2010. J. Biol. Chem. 286, 1737.
    产品信息
    形式 Orange-yellow solid
    Hill配方 C₁₃H₁₂N₆O₂
    化学配方 C₁₃H₁₂N₆O₂
    Molar Mass 284.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,385570,Heat Shock Factor 1 Inhibitor, KRIBB11 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,407625,STAT3 Inhibitor XVI - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,05-379,Anti-E2F-1 Antibody, clones KH20 and KH95


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