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描述 概述 Full length, recombinant, human histone deacetylase 8 (HDAC8) fused to at the C-terminus to a His•Tag® sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening. 产品目录编号 382184 品牌系列 Calbiochem®
同义词 HDAC8, Human, Recombinant 参考 参考 Waltregny, D., et al. 2005. FASEB J. 19, 966.
Buggy, J.J., et al. 2000. Biochem J. 350, 199产品信息 形式 Liquid 配方 In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN®-20 detergent, pH 8.0. Molar Mass 46400 生物信息 纯度 ≥90% by SDS-PAGE 特异活性 ≥10 units/µg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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