merck millipore,默克密理愽
  • merck millipore,默克密理博,14-759,Abl (Y253F) Protein, active, 10 µg

  • merck millipore,默克密理博,14-759,Abl (Y253F) Protein, active, 10 µg

    产品名称：Abl (Y253F) Protein, active, 10 µg
    产品型号：14-759
    Active, N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the Y253F mutation. For use in Kinase Assays.

    merck millipore,默克密理博,14-759,Abl (Y253F) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-759,Abl (Y253F) Protein, active, 10 µg

    描述
    产品目录编号 14-759
    品牌系列 Upstate
    商名
    • Upstate
    描述 Abl (Y253F) Protein, active, 10 µg
    概述 N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the Y253F mutation.
    背景信息 The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Y253F mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).
    产品信息
    演示 50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.
    应用
    应用 Active, N-terminal 6His-tagged recombinant human Abl, residues 27-end containing the Y253F mutation. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • U07563
    基因符号
    • bcr/abl
    • ABL1
    • JTK7
    • ABL
    • p150
    • vABL
    • cABL
    蛋白靶 Abl
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P00519
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Abltide.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 10 µg
    包装 Also available in 250μg size as catalog # 14-759M - Call for pricing and availability.

    merck millipore,默克密理博,14-759,Abl (Y253F) Protein, active, 10 µg

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