merck millipore,默克密理博,344580,FtsZ Polymer Stabilizer, PC190723

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Merck Millipore 默克密理愽

merck millipore,默克密理博,344580,FtsZ Polymer Stabilizer, PC190723 - Calbiochem

经验配方
C₁₄H₈ClF₂N₃O₂S

描述
概述	A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC₅₀ = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
产品目录编号	344580
品牌系列	Calbiochem®
同义词	3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer

参考
参考	Elsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342. Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239. Haydon, D. J., et al. 2008. Science, 321, 1673. Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.

生物信息
主靶	FtsZ
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,344580,FtsZ Polymer Stabilizer, PC190723 - Calbiochem

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