merck millipore,默克密理博,373276,Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4

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Merck Millipore 默克密理愽

merck millipore,默克密理博,373276,Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem

经验配方	CAS号
C₂₀H₂₃N₅O	796887-98-4

描述
概述	A cell-permeable piperazinyl-quinazoline compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu^+/+ NIH 3T3 (shh-LIGHT2) and Sufu^-/- fibroblast cultures (IC₅₀ = 3 & 9 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-1 (Cat. No. 373275) and GANT-61 (Cat. No. 373401). However, unlike HPI-1, HPI-3's inhibitory activity against Su(fu)^-/- fibroblasts is completely abolished by Gli1 or Gli2 overexpression. While both HPI-1 and HPI-3 are shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing NIH 3T3 cultures (IC₅₀ = 2.5 & 1 µM, respectively), only HPI-1, but not HPI-3, is able to effectively suppress the SmoM2-induced Hh pathway activation in primary murine CGNPs (Cerebellar Granule Neuron Precursors) cultures.
产品目录编号	373276
品牌系列	Calbiochem®
同义词	2-((-(4-Phenylpiperazin-4-yl)quinazolin-4-yl)amino)ethanol

参考
参考	Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,373276,Hh Signaling Antagonist XIII, HPI-3 - CAS 796887-98-4 - Calbiochem

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