merck millipore,默克密理愽
  • merck millipore,默克密理博,371825,GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem

  • merck millipore,默克密理博,371825,GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem

    产品名称：GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem
    产品型号：371825
    The GPCR-Helix 8 Signaling Inhibitor, JF5 controls the biological activity of GPCR-Helix 8. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,371825,GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,371825,GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₂₂N₂ • HI
    描述
    概述 A cell-permeable quinolinimine compound that acts as a selective, potent blocker of G-protein coupled receptors (GPCR) that contain a constrained eighth helix (H8). The inhibition is selective and blocks G-protein signaling mediated via Gαq, but not Gα12. A non-orthosteric antagonist of PAR1 (IC50 = 4 µM) that is shown to inhibit PAR1 and CCR-4 induced platelet aggregation without affecting PAR4 mediated aggregation. Shown to inhibit thrombus formation following vascular injury (IC50 ~1 mg/kg). Also acts as a potent, non-competitive blocker of α2A-adrenergic receptors (IC50 = 2.5 µM as shown by a decrease in 3H-yohimbine binding).
    产品目录编号 371825
    品牌系列 Calbiochem®
    同义词 4-Pentyl-2,3-dihydro-1H-cyclopenta[b]quinolin-9-imine, HI, 4-Pentyl-1,2,3,4-tetrahydro-9H-cyclopenta[b]quinolin-9-imine, HI, GPCR-H8 Signaling Inhibitor, JF5
    参考
    参考 Dowal, L., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 2951.
    产品信息
    形式 Off-white powder
    Hill配方 C₁₇H₂₂N₂ • HI
    化学配方 C₁₇H₂₂N₂ • HI
    Molar Mass 382.3
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥92% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,371825,GPCR-Helix 8 Signaling Inhibitor, JF5 - Calbiochem

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