merck millipore,默克密理愽
  • merck millipore,默克密理博,23-058,Smurf1, active

  • merck millipore,默克密理博,23-058,Smurf1, active

    产品名称：Smurf1, active
    产品型号：23-058


    merck millipore,默克密理博,23-058,Smurf1, active

  • 产品介绍
  • merck millipore,默克密理博,23-058,Smurf1, active

    描述
    产品目录编号 23-058
    品牌系列 Upstate
    商名
    • Upstate
    描述 Smurf1, active
    长描述 N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.
    Alternate Names
    • SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1
    背景信息 Smurf1 is a member of the Nedd4-like family of E3 ligases. It contains an amino terminal C2 domain and 2 WW domains that are responsible for cellular localization and substrate recognition, and a catalytic carboxyl terminal HECT domain.
    Smurf1 was originally identified as a negative regulator of the TGF-β/BMP (bone morphogenetic proteins) signalling pathway by degrading SMAD proteins and TGF-β /BMP receptors. To date, over a dozen substrates have been identified, including Runx2, MEKK2, RhoA, Par6, JunB, Talin head, Prickle1, TRAF family proteins, and STAT1. This suggests a pleiotropic role for Smurf1 in various cellular functions such as bone homeostasis, embryonic development, cell movement and polarity control, and immune response. Aberrant expression of Smurfs has been shown to occur in several types of cancers, including breast, oesophageal, pancreatic and renal cell carcinomas.
    应用
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    级联部件 E3
    Entrez基因编号
    • NM_181349
    纯化方法 Purified using glutathione sepharose.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,23-058,Smurf1, active

上一件merck millipore产品：merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,05-740,Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12


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