merck millipore,默克密理愽
  • merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg

  • merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg

    产品名称：PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg
    产品型号：14-781M
    Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation E545K & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

    merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg

    描述
    产品目录编号 14-781M
    商名
    • Upstate
    描述 PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg
    概述 Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation E545K and untagged, recombinant, full length mouse p85α.
    背景信息 The E545K substitution is associated with a number of human cancers. This residue is conserved between the human and mouse sequences of p110α. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation.
    应用
    应用 Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation E545K & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Coexpressed by baculovirus in Sf21 insect cells.
    品种 Mouse
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006218.2
    Entrez基因汇总 Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
    基因符号
    • MGC142163
    • PIK3CA
    • PI3K
    • MGC142161
    • p110-alpha
    蛋白靶 PI3Kα/p85α
    纯化方法 Ni2+/NTA-agarose
    靶子系列 PI3K/PI4K
    UniProt编号
    • P42336
    UniProt汇总 FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
    SIZE: 1068 amino acids; 124284 Da
    SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
    DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
    SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-781) and in bulk (cat# 14-781-K).

    merck millipore,默克密理博,14-781M,PI3 Kinase (p110α(E545K)/p85α), Murine, 250 µg

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