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merck millipore,默克密理博,197320,Bcl-2 Converter, D-NuBCP-9-r8, Cell-permeable - Calbiochem
产品名称：Bcl-2 Converter, D-NuBCP-9-r8, Cell-permeable - Calbiochem
产品型号：197320
An all-D-amino acid version of the Nur77-derived minimum Bcl-2/Bcl-B/Bfl-1-conformation converting sequence is conjugated with a D-Arg octamer to facilitate its cellular delivery.
merck millipore,默克密理博,197320,Bcl-2 Converter, D-NuBCP-9-r8, Cell-permeable - Calbiochem
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重要规格表
经验配方 C₁₀₆H₁₉₁N₄₉O₂₃ 描述 概述 An all-D-amino acid version of the Nur77-derived minimum Bcl-2/Bcl-B/Bfl-1-conformation converting sequence is conjugated with a D-Arg octamer to facilitate its cellular delivery. CD binding studies reveal a 1:1 stoichiometric binding and that Bcl-2 unstructured loop region (aa 29-90) as the main D-NuBCP-9 interacting site with possible additional involvement of the BH4 domain. D-NuBCP-9-induced apoptosis is Bcl-2-dependent (100% vs 0% inhibition, respectively, of MEF vs Bcl-2-/- MEF colonies formation by 15 µM D-NuBCP-9) and requires the presence of either Bak or Bax (0% inhibition of Bax-/-Bak-/- MEF colonies formation). D-NuBCP-9-induced apoptosis in HeLa cultures is also demonstrated to be potentiated by 114% and 78%, respectively, upon vector expression of Bcl-B or Bfl-1. When applied to MDA-MB435-xenografted mice on the 10th & 13th day after cancer cell implant, D-NuBCP-9 (620 µg/mouse) reportedly suppressed tumor growth (by 80% on day 55) by inducing cancer cell apoptosis in vivo. 产品目录编号 197320 品牌系列 Calbiochem®
同义词 (D)-Ac-fsrslhsll-G-NH(CH₂)₅-CO-rrrrrrrr-NH₂, D-NuBCP-9 参考 参考 Kolluri, S.K., et al. 2008. Cancer Cell 14, 285. 产品信息 形式 Lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₁₀₆H₁₉₁N₄₉O₂₃ 化学配方 C₁₀₆H₁₉₁N₄₉O₂₃ Molar Mass 2520. 吸湿 Hygroscopic
肽序列 (D)-Ac-phe-ser-arg-ser-leu-his-ser-leu-leu-Gly-NH-(CH₂)₅-CO-arg-arg-arg-arg-arg-arg-arg-arg-NH₂ 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O or DMSO 肽序列 (D)-Ac-phe-ser-arg-ser-leu-his-ser-leu-leu-Gly-NH-(CH₂)₅-CO-arg-arg-arg-arg-arg-arg-arg-arg-NH₂ 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,9601-OP,OmniPur Water, DEPC Treated, Sterile, Nuclease-Free - CAS 7732-18-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,FCABS352A4,Milli-Mark™ Anti-Nanog-Alexa Fluor 488 Antibody, NT
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