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merck millipore,默克密理博,370700,GW9662 - CAS 22978-25-2 - Calbiochem
产品名称：GW9662 - CAS 22978-25-2 - Calbiochem
产品型号：370700
A cell-permeable, selective and irreversible PPARγ antagonist (IC₅₀ = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively).
merck millipore,默克密理博,370700,GW9662 - CAS 22978-25-2 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₃H₉ClN₂O₃ 22978-25-2 描述 概述 A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-α (LXRα), retinoic acid receptor (RAR), retinoid X receptor-α (RXRα) and thyroid receptors α and β (TRα and TRβ). 产品目录编号 370700 品牌系列 Calbiochem®
同义词 2-Chloro-5-nitro-N-phenylbenzamide 参考 参考 Leesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
Huang, J.T., et al. 1999. Nature 400, 378.产品信息 CAS号 22978-25-2 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₁₃H₉ClN₂O₃ 化学配方 C₁₃H₉ClN₂O₃ Molar Mass 276.7 可逆 N 结构配方图像 生物信息 主靶 PPARγ 主靶IC50 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MetOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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