merck millipore,默克密理博,344930,Furin Inhibitor I

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,344930,Furin Inhibitor I - Calbiochem
产品名称：Furin Inhibitor I - Calbiochem
产品型号：344930
The Furin Inhibitor I controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

merck millipore,默克密理博,344930,Furin Inhibitor I - Calbiochem

产品介绍

merck millipore,默克密理博,344930,Furin Inhibitor I - Calbiochem

重要规格表

经验配方
C₃₄H₆₆ClN₁₁O₅

描述
概述	A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
产品目录编号	344930
品牌系列	Calbiochem®
同义词	Decanoyl-RVKR-CMK

参考
参考	Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375. Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Denault, J.B., et al. 1995. FEBS Lett. 362, 276. Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47. Garten, W., et al. 1994. Biochimie 76, 217. Hallenberger, S., et al. 1992. Nature 360, 358. Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

参考

Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

产品信息
具有ATP竞争性	N
形式	Off-white solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₃₄H₆₆ClN₁₁O₅
化学配方	C₃₄H₆₆ClN₁₁O₅
Molar Mass	744.4
肽序列	Decanoyl-Arg-Val-Lys-Arg-CMK
可逆	N
结构配方图像

生物信息
主靶	viral glycoproteins
纯度	≥90% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO
肽序列	Decanoyl-Arg-Val-Lys-Arg-CMK

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.