merck millipore,默克密理博,627610,Caspase Inhibitor I - CAS 187389-52-2

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merck millipore,默克密理博,627610,Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem
产品名称：Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem
产品型号：627610
The Caspase Inhibitor I, also referenced under CAS 187389-52-2, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

merck millipore,默克密理博,627610,Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem

产品介绍

merck millipore,默克密理博,627610,Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem

重要规格表

经验配方	CAS号
C₂₂H₃₀FN₃O₇	187389-52-2

描述
概述	A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
产品目录编号	627610
品牌系列	Calbiochem®
同义词	Z-VAD (OMe)-FMK

参考
参考	Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. Martin, U., et al. 2007. Apoptosis 12, 525. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. Cain, K., et al. 1996. Biochem J. 314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J. 315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett. 374, 303.

参考

Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
Martin, U., et al. 2007. Apoptosis 12, 525.
Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
Cain, K., et al. 1996. Biochem J. 314, 27.
Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
Pronk, G.J., et al. 1996. Science 271, 808.
Slee, E.A., et al. 1996. Biochem. J. 315, 21.
Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
Zhu, H., et al. 1995. FEBS Lett. 374, 303.

产品信息
CAS号	187389-52-2
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₂H₃₀FN₃O₇
化学配方	C₂₂H₃₀FN₃O₇
Molar Mass	467.5
肽序列	Z-Val-Ala-Asp(OMe)-CH₂F*
可逆	N
结构配方图像

生物信息
主靶	Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
纯度	Single spot by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO
肽序列	Z-Val-Ala-Asp(OMe)-CH₂F*

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.