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经验配方 CAS号 C₆H₅AsO 637-03-6 描述 概述 A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts). 产品目录编号 521000 品牌系列 Calbiochem®
同义词 PAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX 参考 参考 Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Carey, J.O., et al. 1995. Diabetes 44, 1995.
Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem. 270, 2067.
Oetken, C., et al. 1995. Mol. Immunol. 31, 1295.
Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem. 270, 10631.产品信息 CAS号 637-03-6 具有ATP竞争性 N 形式 White solid Hill配方 C₆H₅AsO 化学配方 C₆H₅AsO Molar Mass 168.0 可逆 N 结构配方图像 生物信息 主靶 Protein tyrosine phosphatase 主靶IC50 18 µM against protein tyrosine phosphatase 纯度 ≥96% by titration 理化信息 细胞可渗透 N 溶解度 CHCl₃ or DMSO GHS安全信息 RTECS CH8100000 安全信息 R相 R: 26/27/28-34-40
Very toxic by inhalation, in contact with skin and if swallowed.
Causes burns.
Limited evidence of a carcinogenic effect.S相 S: 26-27-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Highly Toxic & Carcinogenic / Teratogenic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
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