merck millipore,默克密理博,344273,Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,344273,Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

经验配方	CAS号
C₂₉H₄₈N₂O₇ · 2HCl	115116-37-5

描述
概述	Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC₅₀ = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.
产品目录编号	344273
品牌系列	Calbiochem®
同义词	L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl

参考
参考	Yang, C.M., et al. 1999. Cell Signal. 11, 697. Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880. Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255. Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.

生物信息
主靶	Adenylate cyclase
主靶IC₅₀	EC50 = 13 µM in activating adenylate cyclase
纯度	≥92% by HPLC

理化信息
细胞可渗透	N
溶解度	MeOH or H₂O

安全信息
R相	R: 21 Harmful in contact with skin.
S相	S: 36 Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Harmful
储存	+15°C to +30°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

merck millipore,默克密理博,344273,Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

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