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merck millipore,默克密理博,14-587M,p38α/SAPK2a (6His-tag) Protein, active, 250 µg
产品名称：p38α/SAPK2a (6His-tag) Protein, active, 250 µg
产品型号：14-587M
Active, N-terminal His6-tagged, recombinant human full-length p38a/SAPK2a, for use in Kinase Assays.
merck millipore,默克密理博,14-587M,p38α/SAPK2a (6His-tag) Protein, active, 250 µg
- 产品介绍
描述 产品目录编号 14-587M 品牌系列 Upstate
商名 - Upstate
描述 p38α/SAPK2a (6His-tag) Protein, active, 250 µg 概述 N-terminal His6-tagged, recombinant human full-length p38a/SAPK2a 应用 应用 Active, N-terminal His6-tagged, recombinant human full-length p38a/SAPK2a, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli, activated using DD-MKK6 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_139014.1
- NM_001315.1
- NM_139012.1
- NM_139013.1
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. 基因符号 - CSBP2
- MAPK14
- p38
- CSBP
- PRKM15
- PRKM14
- RK
- SAPK2A
- CSBP1
- CSPB1
- Mxi2
- p38ALPHA
- MXI2
- EXIP
蛋白靶 p38α/SAPK2a 纯化方法 Ni2+/NTA-agarose 靶子系列 CMGC UniProt编号 - Q16539
UniProt汇总 FUNCTION: SwissProt: Q16539 # Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
COFACTOR: Magnesium.
SIZE: 360 amino acids; 41293 Da
SUBUNIT: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity). Interacts with NP60.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
TISSUE SPECIFICITY: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.DOMAIN:SwissProt: Q16539 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme. & Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP (Catalog #13-104) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -20°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-587) and in bulk (cat# 14-587-K).
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