merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1549,Anti-SAP130 Antibody, clone 1YO 1B10

  • merck millipore,默克密理博,04-1549,Anti-SAP130 Antibody, clone 1YO 1B10

    产品名称：Anti-SAP130 Antibody, clone 1YO 1B10
    产品型号：04-1549
    Use Anti-SAP130 Antibody, clone 1YO 1B10 (Mouse Monoclonal Antibody) validated in WB, ICC to detect SAP130 also known as 130 kDa Sin3-associated polypeptide, SF3b130.

    merck millipore,默克密理博,04-1549,Anti-SAP130 Antibody, clone 1YO 1B10

  • 产品介绍
  • merck millipore,默克密理博,04-1549,Anti-SAP130 Antibody, clone 1YO 1B10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1549
    描述 Anti-SAP130 Antibody, clone 1YO 1B10
    Alternate Names
    • SF3b130
    • 130 kDa Sin3-associated polypeptide
    • Sin3-associated polypeptide p130
    • Sin3A-associated protein, 130kDa
    • histone deacetylase complex subunit SAP130
    • mSin3A-associated protein 130 <br />Spliceosome-associated protein 130
    • Pre-mRNA-splicing factor SF3b 130 kDa subunit
    背景信息 SAP130, also known as Splicing factor 3B subunit 3, is part of the RNA splicing machinery. It is expressed by the Sf3b3 gene and encodes subunit 3 of the splicing factor 3b protein complex. As a component of this protein complex, it is associated with U2 snRNP and recruited to prespliceosomal complexes. Splicing factor 3b along with splicing factor 3a and a 12S RNA, form the U2 small nuclear ribonucleoprotein complex (U2 snRNP). In pre-mRNA’s, the splicing factor 3b/3a complex binds upstream of intron branch sites possibly anchoring the U2 snRNP to the pre-mRNA.
    SAP130 is also a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes are believed to function in chromatin modification, transcription, splicing, and DNA repair.
    产品信息
    格式 Ascites
    控制
    • RAW264.7 cell lysate
    演示 Unpurified mouse monoclonal IgG1κ preservative-free ascites.
    应用
    应用 Use Anti-SAP130 Antibody, clone 1YO 1B10 (Mouse Monoclonal Antibody) validated in WB, ICC to detect SAP130 also known as 130 kDa Sin3-associated polypeptide, SF3b130.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected SAP130 in NIH/3T3 cells.
    生物信息
    免疫原品种 Ovalbumin-conjugated linear peptide corresponding to mouse SAP130.
    表位 Unknown
    克隆 clone 1YO 1B10
    宿主 Mouse
    特异性 This antibody recognizes SAP130.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_598714.1
    基因符号
    • Kiaa0017
    • SAP130
    • Sf3b3
    纯化方法 Unpurified
    UniProt编号
    • Q921M3
    UniProt汇总 FUNCTION: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron by similarity.

    SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interaction between SF3B3 and SF3B1 is tighter than the interaction between SF3B3 and SF3B2. Associates with the STAGA transcription coactivator-HAT complex. Interacts with SUPT3H by similarity.

    SUBCELLULAR LOCATION: Nucleus by similarity.

    SEQUENCE SIMILARITIES: Belongs to the RSE1 family.
    产品使用声明
    质量保证 Evaluated by Western Blot in RAW264.7 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected SAP130 on 10 µg of RAW264.7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1549,Anti-SAP130 Antibody, clone 1YO 1B10

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