merck millipore,默克密理愽
  • merck millipore,默克密理博,328010,InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

  • merck millipore,默克密理博,328010,InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

    产品名称：InSolution™ ERK Inhibitor II, FR180204 - Calbiochem
    产品型号：328010
    The InSolution™ ERK Inhibitor II, FR180204, also referenced under CAS 865362-74-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephos More>>

    merck millipore,默克密理博,328010,InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,328010,InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₃N₇
    描述
    概述 A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control (Cat. No. 328008) and the solid form of this compound (Cat. No. 328007) are also available..
    产品目录编号 328010
    品牌系列 Calbiochem®
    参考
    参考 Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
    产品信息
    形式 Liquid
    配方 A 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
    Hill配方 C₁₈H₁₃N₇
    化学配方 C₁₈H₁₃N₇
    Molar Mass 327.3
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,328010,InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

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