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merck millipore,默克密理博,324519,InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
产品名称：InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
产品型号：324519
merck millipore,默克密理博,324519,InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,324519,InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
重要规格表
经验配方 CAS号 C₁₈H₁₂Cl₂N₄O₄S 315706-13-9 描述 概述 A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice. 产品目录编号 324519 品牌系列 Calbiochem®
同义词 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I 参考 参考 Gkogkas, C.G., et al. 2012. Nature 493, 371.
Moerke, N. J., et al. 2007. Cell 128, 257.产品信息 CAS号 315706-13-9 形式 Liquid 配方 A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517) Hill配方 C₁₈H₁₂Cl₂N₄O₄S 化学配方 C₁₈H₁₂Cl₂N₄O₄S Molar Mass 451.3 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 eIF4E 主靶Ki 25 µ 纯度 ≥95% by HPLC (sum of two isomers) 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Dry Ice Only
毒性 Irritant
储存 ≤ -70°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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