merck millipore,默克密理博,475838,Mifepristone - CAS 84371-65-3

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merck millipore,默克密理博,475838,Mifepristone - CAS 84371-65-3 - Calbiochem
产品名称：Mifepristone - CAS 84371-65-3 - Calbiochem
产品型号：475838
A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

merck millipore,默克密理博,475838,Mifepristone - CAS 84371-65-3 - Calbiochem

产品介绍

merck millipore,默克密理博,475838,Mifepristone - CAS 84371-65-3 - Calbiochem

重要规格表

经验配方	CAS号
C₂₉H₃₅NO₂	84371-65-3

描述
概述	A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.
产品目录编号	475838
品牌系列	Calbiochem®
同义词	(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486

参考
参考	McCullers, D.L., et al. 2002. Neuroscience 109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res. 61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912. Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280. Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

参考

McCullers, D.L., et al. 2002. Neuroscience 109, 219.
Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

产品信息
CAS号	84371-65-3
具有ATP竞争性	N
形式	Yellow solid
Hill配方	C₂₉H₃₅NO₂
化学配方	C₂₉H₃₅NO₂
Molar Mass	429.6
可逆	N
结构配方图像

生物信息
主靶	Progesterone and glucocorticoid receptors
纯度	≥99% by titration

理化信息
细胞可渗透	Y
污染物	Steroid substances: ≤0.1%
溶解度	EtOH

GHS安全信息
RTECS	KG2955000

安全信息
R相	R: 60-61 May impair fertility. May cause harm to the unborn child.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.