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merck millipore,默克密理博,238806,Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem
产品名称：Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem
产品型号：238806
The Cdk2/9 Inhibitor, also referenced under CAS 507487-89-0, controls the biological activity of Cdk2/9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica More>>
merck millipore,默克密理博,238806,Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₁₂N₆O₂S 507487-89-0 描述 概述 A cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition. 产品目录编号 238806 品牌系列 Calbiochem®
同义词 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III 参考 参考 Kontopidis, G., et al. 2006. Chem. Biol. 13, 201.
Wang, S., et al. 2004. J. Med. Chem. 47, 1662.产品信息 CAS号 507487-89-0 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₁₄H₁₂N₆O₂S 化学配方 C₁₄H₁₂N₆O₂S Molar Mass 328.4 可逆 N 结构配方图像 生物信息 主靶 Cdk2/E and Cdk9/T1 主靶Ki 2 nM and 4 nM against Cdk2/E and Cdk9/T1, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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