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品种反应性 主要应用 宿主 格式 抗体类型 Pm, H, R, Chp ELISA, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-066 描述 Anti-ASPM Antibody Alternate Names - microcephaly, primary autosomal recessive 5
- Abnormal spindle protein homolog
- Asp homolog
- asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
- asp (abnormal spindle)-like, microcephaly associated
- asp (abnormal spindle)-like, microcephaly associated (Drosophila)
背景信息 The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis. 产品信息 格式 Affinity Purified 控制 - Human ductal carcinoma tissue
演示 Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-ASPM Antibody detects level of ASPM & has been published & validated for use in IH, ELISA. 主要应用 - ELISA
- Immunohistochemistry
应用说明 ELISA: Tested in direct ELISA against the ASPM immunogen. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ASPM. 表位 N/A 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes ASPM. 品种反应性 PrimateHumanRatChimpanzee Species Reactivity Note Reacts with human. Predicted to react with chimpanzee and primate based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_060606
Entrez基因汇总 The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis. 基因符号 - MCPH5
- ASPM
- ASP
- Calmbp1
纯化方法 Affinity Purfied UniProt编号 - Q8IZT6
UniProt汇总 FUNCTION: Probable role in mitotic spindle regulation and coordination of mitotic processes By similarity. May have a preferential role in regulating neurogenesis.
SUBCELLULAR LOCATION: Cytoplasm by similarity. Nucleus By similarity. Note: The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin by similarity.
INVOLVEMENT IN DISEASE: Defects in ASPM are the cause of microcephaly primary type 5 (MCPH5) [MIM:608716]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
SEQUENCE SIMILARITIES: Contains 2 CH (calponin-homology) domains.
Contains 39 IQ domains.产品使用声明 质量保证 Immunohistochemistry Analysis: 1:300 dilution of this antibody detected ASPM in human ductal carcinoma tissue. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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