merck millipore,默克密理愽
  • merck millipore,默克密理博,220491,InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

  • merck millipore,默克密理博,220491,InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

    产品名称：InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
    产品型号：220491
    The InSolution™ Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>

    merck millipore,默克密理博,220491,InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,220491,InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₄ClN₃O₂516480-79-8
    描述
    概述 A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
    产品目录编号 220491
    品牌系列 Calbiochem®
    同义词 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
    参考
    参考 Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
    产品信息
    CAS号 516480-79-8
    形式 Liquid
    配方 Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
    Hill配方 C₂₀H₁₄ClN₃O₂
    化学配方 C₂₀H₁₄ClN₃O₂
    Molar Mass 363.8
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,220491,InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

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