merck millipore,默克密理愽
  • merck millipore,默克密理博,14-623,HIPK2 Protein, active, 10 µg

  • merck millipore,默克密理博,14-623,HIPK2 Protein, active, 10 µg

    产品名称：HIPK2 Protein, active, 10 µg
    产品型号：14-623
    Active, N-terminal His6-tagged, recombinant, human HIPK2, amino acids 165-564, for use in Kinase Assays.

    merck millipore,默克密理博,14-623,HIPK2 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-623,HIPK2 Protein, active, 10 µg

    描述
    产品目录编号 14-623
    品牌系列 Upstate
    商名
    • Upstate
    描述 HIPK2 Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant, human HIPK2, amino acids 165-564
    应用
    应用 Active, N-terminal His6-tagged, recombinant, human HIPK2, amino acids 165-564, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_022740.2
    Entrez基因汇总 HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.[supplied by OMIM]
    基因符号
    • hHIPk2
    • HIPK2
    • PRO0593
    蛋白靶 HIPK2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • Q9H2X6
    UniProt汇总 FUNCTION: SwissProt: Q9H2X6 # Protein kinase acting as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. Phosphorylation of TP53 may be mediated by a TP53-HIPK2-AXIN1 complex. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB (By similarity). Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity.
    SIZE: 1198 amino acids; 130966 Da
    SUBUNIT: Interacts with TRADD, TP53, TP73, TP63, CREBBP, DAXX, P53DINP1, SKI, SMAD1, SMAD2 and SMAD3, but not SMAD4. Interacts with NKX1-2, NKX2-5, SPN/CD43, UBE2I, HMGA1, CTBP1, AXIN1, NLK, MYB, POU4F1, POU4F2, POU4F3, UBE2I, UBL1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Interacts with CBX4.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.TISSUE SPECIFICITY: Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors.
    PTM: Phosphorylated on tyrosines (By similarity). Autophosphorylated. & Sumoylated. When conjugated it is directed to nuclear speckles. Desumoylated by SENP1 (By similarity). Sumoylation on Lys-32 is promoted by the E3 SUMO-protein ligase CBX4.
    SIMILARITY: SwissProt: Q9H2X6 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of 0.33mg/ml MBP (Catalog # 13-104)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-623,HIPK2 Protein, active, 10 µg

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