merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC34,Anti-Beclin-1 Antibody, clone 9A1.1

  • merck millipore,默克密理博,MABC34,Anti-Beclin-1 Antibody, clone 9A1.1

    产品名称：Anti-Beclin-1 Antibody, clone 9A1.1
    产品型号：MABC34
    Anti-Beclin-1 Antibody, clone 9A1.1 detects level of Beclin-1 & has been published & validated for use in Western Blotting, IHC(P), Flow Cytometry.

    merck millipore,默克密理博,MABC34,Anti-Beclin-1 Antibody, clone 9A1.1

  • 产品介绍
  • merck millipore,默克密理博,MABC34,Anti-Beclin-1 Antibody, clone 9A1.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC34
    Replaces MABN16
    描述 Anti-Beclin-1 Antibody, clone 9A1.1
    Alternate Names
    • Protein GT197
    • Beclin-1
    • Coiled-coil myosin-like BCL2-interacting protein
    背景信息 The Beclin-1 (BECN1) gene encodes a 60 kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity, tumorigenesis, and has been found to ameliorate the neurodegenerative pathology in α-Synuclein models of Parkinson's and lewy body diseases. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport (3).
    产品信息
    格式 Purified
    控制
    • Raji cell lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Beclin-1 Antibody, clone 9A1.1 detects level of Beclin-1 & has been published & validated for use in Western Blotting, IHC(P), Flow Cytometry.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Beclin-1 in human colorectal adenocarcinoma tissue.

    Flow Cytometry Analysis: 1 µg from a representative lot detected Beclin-1 in HeLa cells.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human Beclin-1.
    克隆 9A1.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_003757
    基因符号
    • GT197
    • BECN1
    纯化方法 Protein G purified
    UniProt编号
    • Q14457
    产品使用声明
    质量保证 Evaluated by Western Blot in Raji cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Beclin-1 in 10 µg of Raji cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC34,Anti-Beclin-1 Antibody, clone 9A1.1

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