merck millipore,默克密理愽
  • merck millipore,默克密理博,14-444,PKC θ Protein, active, 10 µg

  • merck millipore,默克密理博,14-444,PKC θ Protein, active, 10 µg

    产品名称：PKC θ Protein, active, 10 µg
    产品型号：14-444
    Active, recombinant full-length human PKC theta with a C-terminal 6His-tag. For use in Kinase Assays.

    merck millipore,默克密理博,14-444,PKC θ Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-444,PKC θ Protein, active, 10 µg

    描述
    产品目录编号 14-444
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKC θ Protein, active, 10 µg
    概述 Recombinant full-length human PKC theta with a C-terminal 6His-tag

    PKC Lipid activator (Catalog # 20-133) is required for use.
    应用
    应用 Active, recombinant full-length human PKC theta with a C-terminal 6His-tag. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006257.2
    Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
    基因符号
    • nPKC-theta
    • PRKCQ
    • OTTHUMP00000043365
    • MGC126514
    • OTTHUMP00000043364
    • MGC141919
    • PRKCT
    蛋白靶 PKCθ
    纯化方法 immobilized nickel affinity chromatography
    靶子系列 AGC
    UniProt编号
    • Q04759
    UniProt汇总 FUNCTION: SwissProt: Q04759 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
    COFACTOR: Magnesium.
    SIZE: 706 amino acids; 81865 Da
    SUBUNIT: Interacts with TXNL2/PICOT.
    TISSUE SPECIFICITY: Skeletal muscle, megakaryoblastic cells and platelets.
    DOMAIN: SwissProt: Q04759 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
    PTM: Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Histone H1 substrate in vitro
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70 °C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-444,PKC θ Protein, active, 10 µg

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