merck millipore,默克密理愽
  • merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

  • merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

    产品名称：Chk2 Inhibitor, PV1019 - Calbiochem
    产品型号：220488
    The Chk2 Inhibitor, PV1019 controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₇N₇O₃
    描述
    概述 A cell-permeable nitroindolo-guanidinohydrazone compound that acts as a potent, ATP-competitive, and highly selective Chk2 inhibitor (IC50 = 138 and 570 nM against the phosphorylation of histone H1 by Chk2 in the presence of 10 µM and 1 mM of ATP, respectively), while exhibiting much reduced or no activity against a panel of 52 other cellular kinases, including Chk1 (IC50 = 15.73 and 55 µM against substrate phosphorylation and Chk1 autophosphorylation with 10 µM ATP). Shown to effectively suppress radiation-induced phosphorylation of Chk2 (on Ser516) and its downstream substrate Cdc25c (on Ser216) in MCF7 cultures (IC50 <10 µM) and reduce the sensitivity of wild-type murine thymocytes to radiation-induced apoptosis to the level seen in Chk2-/- cultures.
    产品目录编号 220488
    品牌系列 Calbiochem®
    同义词 NSC 744039
    参考
    参考 Jobson, A.G., et al. 2009. J. Pharmacol. Exp. Ther. 331, 816.
    产品信息
    形式 Orange solid
    Hill配方 C₁₈H₁₇N₇O₃
    化学配方 C₁₈H₁₇N₇O₃
    Molar Mass 379.4
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliqout and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,539137,Protease Inhibitor Cocktail Set V, EDTA-Free - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody


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