merck millipore,默克密理愽
  • merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

  • merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

    产品名称：SU5402 - CAS 215543-92-3 - Calbiochem
    产品型号：572630
    A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC₅₀ = 10-20 µM in the presence of 1 mM ATP).

    merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₆N₂O₃215543-92-3
    描述
    概述 A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
    产品目录编号 572630
    品牌系列 Calbiochem®
    同义词 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
    参考
    参考 Mohammadi, M., et al. 1997. Science 276, 955.
    产品信息
    CAS号 215543-92-3
    具有ATP竞争性 Y
    声明 Not available for sale in the United States.
    形式 Lyophilized solid
    Hill配方 C₁₇H₁₆N₂O₃
    化学配方 C₁₇H₁₆N₂O₃
    Molar Mass 296.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Fibroblast growth factor receptor 1 (FGFR1)
    主靶IC50 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,HTS078RTA,Ready-to-Assay™ S1P2 Lysophospholipid Receptor Frozen Cells
下一件merck millipore产品：merck millipore,默克密理博,NS106,Brain Blot, Adult Mouse


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