merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody

  • merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody

    产品名称：Anti-NG2, Alexa Fluor488 Conjugate Antibody
    产品型号：AB5320A4
    Anti-NG2, Alexa Fluor488 Conjugate Antibody detects level of NG2 & has been published & validated for use in ICC & IHC.

    merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, R, M, HIHC, ICCRbAlexaFluor®488Polyclonal Antibody
    描述
    产品目录编号 AB5320A4
    描述 Anti-NG2, Alexa Fluor®488 Conjugate Antibody
    Alternate Names
    • Melanoma-associated chondroitin sulfate proteoglycan
    • Chondroitin sulfate proteoglycan 4
    • Chondroitin sulfate proteoglycan NG2
    • Melanoma chondroitin sulfate proteoglycan
    背景信息 NG2 is a high molecular weight, integral membrane chondroitin sulfate proteoglycan. It is found on the surfaces of an unusual class of glial cells within the developing and mature central nervous system that have the properties of oligodendrocyte precursor cells (i.e., O-2A progenitor cells). NG2 is also found on the surfaces of chondroblasts, proliferating capillary endothelial cells, some human melanoma cell lines, and on leukemic blasts in childhood acute lymphoblastic leukemia. The NG2 proteoglycan is likely to play a role in regulation of cell motility, axon outgrowth and the cellular responses to platelet-derived growth factor.
    产品信息
    格式 AlexaFluor®488
    控制
    • Rat oligodendrocyte precursor cells
    演示 Purified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Anti-NG2, Alexa Fluor®488 Conjugate Antibody detects level of NG2 & has been published & validated for use in ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Immunocytochemistry
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected NG2 in adult rat brain tissue.
    生物信息
    免疫原品种 Immunoaffinity purified NG2 Chondroitin Sulfate Proteoglycan from rat
    宿主 Rabbit
    特异性 This antibody identifies the intact proteoglycan and core protein by WB and ELISA. When oligodendrocyte precursor cells (i.e. O-2A progenitor cells) are stained alive, the stain appears as clusters on the cell surface. This antibody does not stain differentiated oligodendrocytes well.
    品种反应性 MonkeyRatMouseHuman
    Species Reactivity Note Demonstrated to react with Rat. Predicted to react with Mouse, Human, and Monkey based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001888
    Entrez基因汇总 A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
    基因符号
    • MCSP
    • CSPG4
    纯化方法 Protein A adsorption
    UniProt编号
    • Q6UVK1
    UniProt汇总 FUNCTION: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

    SIZE: 2322 amino acids; 250497 Da

    SUBUNIT: Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.

    SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).

    TISSUE SPECIFICITY: Detected only in malignant melanoma cells.

    PTM: N-glycosylated (By similarity). & O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4. & Phosphorylation by PRKCA regulates its subcellular location and function in cell motility (By similarity).

    SIMILARITY: Contains 15 CSPG (NG2) repeats. & Contains 2 laminin G-like domains.

    MISCELLANEOUS: Valuable marker for several incompletely differentiated precursor cells
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in rat oligodendrocyte precursor cells.

    Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected NG2 in rat oligodendrocyte precursor cells. Performed without Triton.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5320A4,Anti-NG2, Alexa Fluor488 Conjugate Antibody

上一件merck millipore产品：merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MERSSTX03,替换电极，1 对


相关产品

merck millipore,默克密理博,ABF243,Anti-CXCR7 Antibody merck millipore,默克密理博,ABF243,Anti-CXCR7 Antibody

merck millipore,默克密理博,SF-1387,ARID2; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1387,ARID2; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,AB9478,Anti-P2Y6 Receptor Antibody merck millipore,默克密理博,AB9478,Anti-P2Y6 Receptor Antibody

merck millipore,默克密理博,539137,Protease Inhibitor Cocktail Set V, EDTA-Free - Calbiochem merck millipore,默克密理博,539137,Protease Inhibitor Cocktail Set V, EDTA-Free - Calbiochem

merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem merck millipore,默克密理博,220488,Chk2 Inhibitor, PV1019 - Calbiochem

merck millipore,默克密理博,MERSSTX03,替换电极，1 对 merck millipore,默克密理博,MERSSTX03,替换电极，1 对

merck millipore,默克密理博,HTS078RTA,Ready-to-Assay™ S1P2 Lysophospholipid Receptor Frozen Cells merck millipore,默克密理博,HTS078RTA,Ready-to-Assay™ S1P2 Lysophospholipid Receptor Frozen Cells

merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem merck millipore,默克密理博,572630,SU5402 - CAS 215543-92-3 - Calbiochem

merck millipore,默克密理博,NS106,Brain Blot, Adult Mouse merck millipore,默克密理博,NS106,Brain Blot, Adult Mouse

merck millipore,默克密理博,SF-2341,TAL1; Human, Cyanine 3 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-2341,TAL1; Human, Cyanine 3 RNA Detection Probe,SmartFlare


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部