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merck millipore,默克密理博,217714,Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem
产品名称：Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem
产品型号：217714
The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation app More>>
merck millipore,默克密理博,217714,Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₃F₂N₇O₂S₂ 443798-55-8 描述 概述 A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM). 产品目录编号 217714 品牌系列 Calbiochem®
同义词 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide 参考 参考 Lin, R., et al. 2005.J. Med. Chem. 48, 4208. 产品信息 CAS号 443798-55-8 具有ATP竞争性 Y 形式 White solid Hill配方 C₁₅H₁₃F₂N₇O₂S₂ 化学配方 C₁₅H₁₃F₂N₇O₂S₂ Molar Mass 425.4 可逆 Y 结构配方图像 生物信息 主靶 Cdk1/cyclin B, Cdk2/cyclin A 主靶IC50 20 nM, 35 nM and 92 nM for anti-proliferative properties in HCT-116, HeLa, and A375 cells, respectively; 600 pM and 500 pM, against Cdk1/cyclin B and Cdk2/cyclin A, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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