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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-665 品牌系列 Upstate
商名 - Upstate
描述 Anti-JAK1 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide 应用 应用 Anti-JAK1 Antibody is an antibody against JAK1 for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein containing amino acids 649-747 of human JAK1 宿主 Rabbit 特异性 JAK1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002227
Entrez基因汇总 Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. 基因符号 - JAK-1
- JAK1
- JAK1B
- JAK1A
纯化方法 Protein A chromatography UniProt编号 - P23458
UniProt汇总 FUNCTION: SwissProt: P23458 # Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
SIZE: 1142 amino acids; 131957 Da
SUBUNIT: Interacts with IL31RA and SHB.
SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
DOMAIN: SwissProt: P23458 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitating JAK1 from human TF1 RIPA lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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