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描述 概述 Native, human, activated C1s complement component. Present in human serum at 31 µg/ml. Nonactivated C1s is found in circulating blood plasma as a Ca2+-dependent dimer in association with one C1q molecule and two C1r molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r protein is cleaved to form activated C1r enzyme. Dimeric C1r enzyme cleaves, and thus activates, each C1s molecule into two disulfide-linked fragments of M.W. 59 kDa and 28 kDa. The 28 kDa peptide contains the C1s enzymatic active site. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4. 产品目录编号 204879 品牌系列 Calbiochem®
参考 参考 Cooper, N.R. 1985. Adv. Immunol. 37, 151.
Sim, R.B. 1981. Methods Enzymol. 80, 6.产品信息 CAS号 80295-35-8 形式 Liquid 配方 In 130 mM NaCl, 50 mM sodium phosphate, pH 7.2. Molar Mass 87000 生物信息 纯度 ≥95% by SDS-PAGE 来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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