merck millipore,默克密理博,09-076,Anti-GATA3 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	09-076
品牌系列	Upstate
商名	Upstate
描述	Anti-GATA3 Antibody
Alternate Names	GATA binding protein 3<br />GATA-binding factor 3 <br />HDR 2<br />Trans-acting T-cell-specific transcription factor GATA-3 <br />MGC2346 <br />MGC5199 <br />MGC5445
背景信息	GATA3 is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional Gata3 knockout mice confirmed the critical role of GATA-3 in helper T cell differentiation and proliferation. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA-3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Blocking GATA-3 action has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear.

产品信息
格式	Affinity Purified
演示	Immunoaffinity purified rabbit IgG in PBS, 0.1% sodium azide.

应用
应用	Use Anti-GATA3 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect GATA3 also known as Trans-acting T-cell-specific transcription factor GATA-3 .
主要应用	Western Blotting

生物信息
免疫原品种	KLH conjugated synthetic peptide (VTADQPRWVSHHHPA(C) corresponding to a.a. 3-17 of human GATA3
表位	a.a. 3-17
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Recognizes GATA3
同种型	IgG
品种反应性	RatHuman
抗体类型	Polyclonal Antibody
Entrez基因编号	2625
基因符号	MGC5445 HDR MGC2346 MGC5199
纯化方法	Immunoaffinity purified
UniProt编号	P23771
UniProt汇总	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Genatlas biochemistry entry for GATA3: T cell specific transcription factor,GATA sequence binding protein in T cell receptor, also expressed in endothelial cell, placenta, transcriptional regulator in kidney, adrenal gland, embryonic brain, adult nervous system endocardium, associated with a special class of nuclear bodies.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

包装信息
数量	100 µg

merck millipore,默克密理博,09-076,Anti-GATA3 Antibody

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