merck millipore,默克密理博,569397,Staurosporine, Streptomyces sp.

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merck millipore,默克密理博,569397,Staurosporine, Streptomyces sp.
产品名称：Staurosporine, Streptomyces sp.
产品型号：569397
A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

merck millipore,默克密理博,569397,Staurosporine, Streptomyces sp.

产品介绍

merck millipore,默克密理博,569397,Staurosporine, Streptomyces sp.

重要规格表

经验配方	CAS号
C₂₈H₂₆N₄O₃	62996-74-1

描述
概述	A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A (IC₅₀ = 7 nM), CaM kinase (IC₅₀ = 20 nM), myosin light chain kinase (IC₅₀ = 1.3 nM), protein kinase C (IC₅₀ = 700 pM), and protein kinase G (IC₅₀ = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁ checkpoint. A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569396) in DMSO is also available.
产品目录编号	569397
品牌系列	Calbiochem®
同义词	PKA Inhibitor II, MLCK Inhibitor I

参考
参考	Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43. Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271. Bruno, S., et al. 1992. Cancer Res. 52, 470. Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853. Vitale, M.L., et al. 1992. Neuroscience 51, 463. Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102. Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

参考

Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
Bruno, S., et al. 1992. Cancer Res. 52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
Vitale, M.L., et al. 1992. Neuroscience 51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

产品信息
CAS号	62996-74-1
具有ATP竞争性	Y
形式	White to pale yellow solid
Hill配方	C₂₈H₂₆N₄O₃
化学配方	C₂₈H₂₆N₄O₃
Molar Mass	466.5
可逆	Y
结构配方图像

生物信息
主靶	PKA
主靶IC₅₀	7 nM, 20 nM, 1.3 nM, 700 pM, and 8.5 nM against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
纯度	≥99% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.