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描述 概述 Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles. 产品目录编号 204863 品牌系列 Calbiochem®
参考 参考 Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.产品信息 形式 Liquid 配方 In PBS, pH 7.2. 防腐剂 None 生物信息 纯度 ≥90% by SDS-PAGE 来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 污染物 IgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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