merck millipore,默克密理愽
  • merck millipore,默克密理博,196805,Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

  • merck millipore,默克密理博,196805,Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

    产品名称：Bax Channel Blocker - CAS 335165-69-0 - Calbiochem
    产品型号：196805
    A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

    merck millipore,默克密理博,196805,Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,196805,Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₁Br₂N₃O • 2CF₃CO₂H335165-69-0
    描述
    概述 A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
    产品目录编号 196805
    品牌系列 Calbiochem®
    同义词 (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, bis TFA, iMAC1
    参考
    参考 Peixoto, P., et al. 2009. Biochem J. 423, 381.
    Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
    产品信息
    CAS号 335165-69-0
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₁₉H₂₁Br₂N₃O • 2CF₃CO₂H
    化学配方 C₁₉H₂₁Br₂N₃O • 2CF₃CO₂H
    Molar Mass 695.3
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 Bax-channel forming activity
    主靶IC50 520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,196805,Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

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