merck millipore,默克密理博,AG782,Angiotensin Converting Enzyme, rat

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merck millipore,默克密理博,AG782,Angiotensin Converting Enzyme, rat
产品名称：Angiotensin Converting Enzyme, rat
产品型号：AG782

merck millipore,默克密理博,AG782,Angiotensin Converting Enzyme, rat

产品介绍

merck millipore,默克密理博,AG782,Angiotensin Converting Enzyme, rat

重要规格表

主要应用	品种	Uni Prot编号
PC	Rat	P47820

描述
产品目录编号	AG782
品牌系列	Chemicon®
商名	Chemicon
描述	Angiotensin Converting Enzyme, rat
概述	ACE (kininase II, EC 3.4.15.1) is a zinc dipeptidyl carboxypeptidase. ACE catalyses both angiotensin I transformation to angiotensis II (a potent vasopressor agent) and degradation of bradikinin, a vaso-depressor. ACE appears to play a key role in regulating vascular tone and remodeling the development of atherosclerotic lesions. Increasing evidence suggests that ACE plays an important role in vascular pathology. Recent studies shows two new functions of this important enzyme: 1) It enhances the presentation of endogenous antigens (in particularly HIV 1 gp160-derived peptide p18) to MHC class I-restricted T-lynphocytes (ref. 1); 2) Its amino-terminal domain cleaves effectively hemoregulatory tetrapeptide N-Ac-Ser-Asp-Lys-Pro (ref. 2,3) which is involved in the control of hemapoetic stem cell proliferation (the amount of this peptide greatly decreases in patients undergoing cancer chemotherapy) (ref. 4).
Alternate Names	Peptidase P ACE CD143 DCP1 Peptidyl-dipeptidase A

产品信息
演示	Liquid in 100 mM phosphate buffered saline, 150 mM NaCl, pH 7.4 with 0.2mM CHAPS. Purity is >95% by SDS-PAGE when 10 μg was loaded. Contains no preservative.

应用
主要应用	Positive Control
应用说明	As a reference in SDS-PAGE and Western blotting [together with anti-ACE monoclonal (MAB4051) also available from Chemicon]. For Western blotting 500 ng/lane if gel is developed with anti-ACE MAB4051. As a reference antigen for immunoprecipitation of ACE from various tissue samples (in combination with anti-ACE MAB4051). As a source of pure ACE for different enzymatic studies of ACE (testing of ACE inhibitors, substrate specificity, kinetic measurements, etc.). Optimal working concentration must be determined by the end user.

应用

主要应用

Positive Control

应用说明

As a reference in SDS-PAGE and Western blotting [together with anti-ACE monoclonal (MAB4051) also available from Chemicon]. For Western blotting 500 ng/lane if gel is developed with anti-ACE MAB4051.

As a reference antigen for immunoprecipitation of ACE from various tissue samples (in combination with anti-ACE MAB4051).

As a source of pure ACE for different enzymatic studies of ACE (testing of ACE inhibitors, substrate specificity, kinetic measurements, etc.).

Optimal working concentration must be determined by the end user.

生物信息
浓缩	Refer to Certificate of Analysis for each individual lot of this enzyme.
来源	Isolated from rat lung using affinity chromatography (ref. 5).
品种	Rat
特异活性	One unit will produce 1 μmoL of hippuric acid or His-Leu from Z-Phe-His-Leu per minute in 0.1 M phosphate buffer and 300 mM NaCl at pH 8.3 at 37°C.
基因符号	DCP1 ACE
UniProt编号	P47820

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.