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merck millipore,默克密理博,MABF12,Anti-Interleukin-17 (IL-17) Antibody, clone 1C12
产品名称：Anti-Interleukin-17 (IL-17) Antibody, clone 1C12
产品型号：MABF12
Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 is an antibody against Interleukin-17 (IL-17) for use in WB.
merck millipore,默克密理博,MABF12,Anti-Interleukin-17 (IL-17) Antibody, clone 1C12
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABF12 Replaces 04-464 描述 Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 Alternate Names - cytotoxic T-lymphocyte-associated protein 8
- interleukin 17A
- interleukin-17A
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- cytotoxic T-lymphocyte-associated serine esterase 8
- Cytotoxic T-lymphocyte-associated antigen 8
背景信息 Interleukin-17 (IL-17) is known to stimulate the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase. TRAF6 is essential in the IL-17 signaling pathway of proinflammatory response. Over-expression of IL-17 by T cells seems to be important in systemic sclerosis pathogenesis. IL-17 is particularly involved in early development of the disease by activating fibroblast propagation and creation of IL-1. IL-17 connects lymphoid and myeloid host defenses and so plays an essential part in the microbial defense response. IL-17 also seems to support the innate immune response by mobilizing neutrophils. IL-17 may be an important clinical target for allergic airway disease. 产品信息 格式 Purified 控制 - Human IL-17 recombinant protein.
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 is an antibody against Interleukin-17 (IL-17) for use in WB. 主要应用 - Western Blotting
应用说明 ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX). 生物信息 免疫原品种 Cohesin-tagged recombinant protein corresponding to human IL-17. 克隆 AB44.57.27E4.1C12 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002181
Entrez基因汇总 The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq]. 基因符号 - CTLA-8
- IL17A
- CTLA8
- IL-17
- IL17
- IL-17A
纯化方法 Protein G Purified UniProt编号 - Q16552
UniProt汇总 FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
SUBUNIT STRUCTURE: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Restricted to activated memory T-cells.
PTM: Found both in glycosylated and nonglycosylated forms.
SEQUENCE SIMILARITIES: Belongs to the IL-17 family.产品使用声明 质量保证 Evaluated by Western Blot in lysate from cells expressing human IL-17 recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-17 recombinant protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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