merck millipore,默克密理愽
  • merck millipore,默克密理博,682160,Xestospongin C, Xestospongia sp. - Calbiochem

  • merck millipore,默克密理博,682160,Xestospongin C, Xestospongia sp. - Calbiochem

    产品名称：Xestospongin C, Xestospongia sp. - Calbiochem
    产品型号：682160
    An oxaquinolizidine alkaloid isolated from a marine sponge.

    merck millipore,默克密理博,682160,Xestospongin C, Xestospongia sp. - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,682160,Xestospongin C, Xestospongia sp. - Calbiochem

    重要规格表

    经验配方
    C₂₈H₅₀N₂O₂
    描述
    概述 An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.
    产品目录编号 682160
    品牌系列 Calbiochem®
    同义词 XeC
    参考
    参考 Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
    Gafni, J., et al. 1997. Neuron 19, 723.
    Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
    Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
    Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
    Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
    产品信息
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₈H₅₀N₂O₂
    化学配方 C₂₈H₅₀N₂O₂
    Molar Mass 446.7
    可逆 Y
    结构配方图像
    生物信息
    主靶 IP3-mediated Ca2+ release
    主靶IC50 358 nM in blocking IP3-mediated Ca2+ release
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, EtOH, or MeOH
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 22-24/25-36/37/39-45

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,682160,Xestospongin C, Xestospongia sp. - Calbiochem

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